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Berenson A, Vardanyan S, David M, Wang J, Harutyunyan NM, Gottlieb J, Halleluyan R, Spektor TM, Udd KA, Eshaghian S, Nassir Y, Eades B, Swift R, Berenson JR Abstract Despite recent advances made in its treatment, multiple myeloma (MM) remains an incurable B cell malignancy. Thus, the objective for treating these patients is to prolong…

Michael Ghermezi, Mingjie Li, Suzie Vardanyan, Nika Manik Harutyunyan, Jillian Gottlieb, Ariana Berenson, Tanya M. Spektor, Claudia Andreu-Vieyra, Sophia Petraki, Eric Sanchez, Kyle Udd, Cathy S. Wang, Regina A. Swift, Haiming Chen, James R Berenson Abstract B-cell maturation antigen is expressed on plasma cells. In this study, we have identified serum B-call maturation antigen as…

Chen H, Li M, Sanchez E, Wang CS, Lee T, Soof CM, Casas CE, Cao J, Xie C, Udd KA, DeCorso K, Tang GY, Spektor TM, Berenson JR. Abstract Tumor necrosis factor receptor-associated factor 6 (TRAF6) has been implicated in polyubiquitin-mediated IL-1R/TLR signaling through activation of IκB kinase (IKK) to regulate the NF-κB and JNK…

Berenson J, Manges R, Badarinath S, Cartmell A, McIntyre K, Lyons R, Harb W, Mohamed H, Nourbakhsh A, Rifkin R Abstract Elotuzumab, an immunostimulatory SLAMF7-targeting monoclonal antibody, induces myeloma cell death with minimal effects on normal tissue. In a previous phase 3 study in patients with relapsed/refractory multiple myeloma (RRMM), elotuzumab (10 mg/kg, ∼3-h infusion),…

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CHAMPION-1: a phase 1/2 study of weekly carfilzomib and dexamethasone for relapsed or relapsed and refractory multiple myeloma Running title (max 50 characters including spaces): Weekly carfilzomib and dexamethasone for RRMM James R. Berenson,1 Alan Cartmell,2 Alberto Bessudo,3 Roger M. Lyons,4 Wael Harb,5 Dimitrios Tzachanis,6 Richy Agajanian,7 Ralph Boccia,8 Morton Coleman,9 Robert A. Moss,10 Robert…

Soluble B-Cell Maturation Antigen Mediates Tumor-Induced Immune Deficiency in Multiple Myeloma Eric Sanchez, Abigail Gillespie, George Tang, Morgan Ferros, Nika Manik Harutyunyan, Suzie Vardanyan, Jillian Gottlieb, Mingjie Li, Cathy S.Wang, Haiming Chen, and James R. Berenson Abstract Purpose: Reduced uninvolved immunoglobulin (Ig) levels are a hallmark of multiple myeloma. We previously showed that Bcell maturation…

James R Berenson, MD,abc Tanya M Spektor, PhD,c and James Wang, MDab aInstitute for Myeloma and Bone Cancer Research; bJames R Berenson, MD, Inc; and cOncotherapeutics, West Hollywood, California Correspondence: James R Berenson, MD; jberenson@imbcr.org. Disclosures: Dr Berenson is a consultant for and receives honoraria and research funding from Takeda, Amgen, Jansen, Celgene, and Bristol-Meyers-Squibb.…

a retrospective cohort study Austin A. Robinson1, James Wang2, Suzie Vardanyan3, Erik K. Madden4, Frank Hebroni4, Kyle A. Udd2, Tanya M. Spektor5, Jason D. Nosrati3, Alex Z. Kitto3, Michael Zahab3, Simrin Cheema6, Darron H. Fors4, Adam Norberg4, Joseph Diehl4, Gabriel N. Waterman7, Regina A. Swift2, John Crowley8, James R. Berenson2,3,5. 1Yale University School of Medicine,…

by James R. Berenson, MD, Inc. Interview with Debra Berenson, myeloma patient advocate, wife of myeloma expert Dr. James Berenson, and author of the book, I Have WHAT?. Debra has collected stories, insights, and tools for and from patients and their families with myeloma and related diseases. The second half of the book includes information…